After finishing her post graduation in Internal Medicine, Dr. Kalke worked for a brief while in critical care and then cardiology before finally moving on to her chosen profession namely Rheumatology. She trained under Dr. V.R. Joshi one of the senior most rheumatologist in India from for 2 years from 1995 to 1997 and then went abroad to Australia and UK for further training and expertise in her profession. Upon her return to India she joined Lilavati Hospitals, Bandra and Shushrusha Hospital Dadar in the year 2002 as a consultant Rheumatologist and continues to be attached to them till date. While continuing her earlier attachments, she joined joined her friend and colleague Dr. Kaushik S. Bhojani at Wockhardt Hospitals near the End of 2007 where they began to work together as a team. In May 2011, She along with her friends, Dr Kaushik and Dr Neelu Bhojani started Kennisha Rheumatology Care and Diagnostics an exclusive center dedicated towards treating and improving the lives of patients with rheumatic Diseases. She is currently involved in clinical research and in training post graduates in medicine in the field of Rheumatology in India along with Dr. Bhojani.